Van Bronckhorst, who won the trophy as a player with Barcelona, guided his side back into the elite competition by winning the Eredivisie for the first time since 1999.
They face off at Stadion Feijenoord on Wednesday night, and speaking ahead of the clash, Van Bronckhorst told NOS that Feyenoord have an advantage at home, but must also be realistic.
He said: “We will miss Nicolai Jorgensen tomorrow but we will have to do it with the players we have in our squad.
”We know what to expect against Manchester City and we are aware of their strengths. We must remain compact and be dangerous on the counter attack.
”It is possible for us to beat Manchester City. We are playing at home. We have played European games at home in the past where people have not expected us to win.
”We must also be realistic that it will be a difficult match because we are facing a very strong opponent.”