Jonny Bairstow will also be released to Yorkshire after the second game of the series. It will be interesting to see if Sam Billings or Jos Buttler take the gloves for England in this series.
Despite the new faces and the resting of Joe Root, Moeen Ali, Adil Rashid and Ben Stokes England still have plenty of established players at their core.
Jason Roy will be desperate to rediscover his form of 2016 and keep his opening partnership with Alex Hales intact. Roy was dropped for the Champions Trophy semi-final defeat to Pakistan but management have shown faith in the Surrey blaster.
England will be without the express pace of Tymal Mills but will be confident that seamers Wood, Overton, Liam Plunkett and David Willey can keep the Proteas in check.
The Proteas will be led by under-fire ODI skipper AB de Villiers, who has been criticized for his leadership in the Champions Trophy. Mister 360 is standing in for regular T20 skipper Faf du Plessis who has returned to South Africa to be with his wife who is expected to give birth to their first child in the coming weeks.
De Villiers leads a side that has no uncapped players but does feature a number of players who are relatively new to the international fold.
Mangaliso Mosehle will attempt to fill the big shoes of Quinton de Kock, at least behind the stumps, with other fringe players Reeza Hendricks and Jon-Jon Smuts set to open the batting.
Cape Cobras seamer Dane Paterson will get another opportunity to impress in the Proteas ghastly yellow T20 shirt having, rather unfairly, copped a lot of flak for his death bowling against Sri Lanka on his debut.
De Villiers himself will look to bridge the gap between the openers and the late order hitters Farhaan Behardien, David Miller and allrounder Chris Morris.