Scrum-half Faf De Klerk has been left out of the Lions squad to face the Brumbies in Canberra on Friday.
Ross Cronjé again starts at number nine while a new front row in Corné Fourie, Robbie Coetzee and Johannes Jonker will get a start in place of Jacques van Rooyen, Malcolm Marx and Ruan Dreyer.
At lock Andries Ferreira returns in the place of Lourens Erasmus while Cyle Brink is replaced by Ruan Ackermann.
A decision on the cover at flank on the bench will be made later in the week with Robert Kruger bracketed with Cyle Brink.
Justin Ackerman will be joining the squad in Australia to provide back-up for the injured Hencus van Wyk.
Lions: 15 Andries Coetzee, 14 Sylvian Mahuza, 13 Lionel Mapoe, 12 Harold Vorster, 11 Courtnal Skosan, 10 Elton Jantjies, 9 Ross Cronjé, 8 Warren Whiteley (c), 7 Ruan Ackermann, 6 Kwagga Smith, 5 Francois Mostert, 4 Andries Ferreira, 3 Johannes Jonker, 2 Robbie Coetzee, 1 Corné Fourie.
Replacements: 16 Malcolm Marx, 17 Jacques van Rooyen, 18 Ruan Dreyer, 19 Lourens Erasmus, 20 Robert Kruger/Cyle Brink, 21 Dillon Smit, 22 Jacques Nel, 23 Anthony Volmink
Date: Friday, May 12
Venue: GIO Stadium, Canberra
Kick-off: 19.45 local (09.45 GMT)
Referee: Paul Williams
Assistant Referees: Nick Briant, Jordan Way
TMO: Ian Smith