In the forwards, flanker Oupa Mohoje returns to action after a month on the sidelines due to concussion sustained while on Springbok duty against France in Durban.
Mohoje will start on the blindside flank while Uzair Cassiem, who did duty there against the Stormers two weeks ago, shifts to the openside where he replaces Henco Venter who is suspended.
The only other change to the pack sees Carl Wegner replacing Armand Koster at lock.
In the back-line, Fred Zeilinga will be starting at fly-half, with Niel Marais dropping down to the bench, while William Small-Smith comes into the run-on side on the right wing where he replaces Sergeal Petersen who is sidelined with a hamstring injury.
Cheetahs: 15 Clayton Blommetjies, 14 William Small-Smith, 13 Francois Venter (c), 12 Clinton Swart, 11 Raymond Rhule, 10 Fred Zeilinga, 9 Tian Meyer, 8 Niell Jordaan, 7 Oupa Mohoje, 6 Uzair Cassiem, 5 Reniel Hugo, 4 Carl Wegner, 3 Johan Coetzee, 2 Elandré Huggett, 1 Ox Nche
Replacements: 16 Joseph Dweba, 17 Charles Marais, 18 Tom Botha, 19 Armandt Koster, 20 Junior Pokomela, 21 Chris Dry, 22 Ruan van Rensburg, 23 Niel Marais
Date: Friday, July 14
Venue: Nelson Mandela Bay Stadium, Port Elizabeth
Kick-off: 19:00 local (17:00 GMT)
Referee: Shuhei Kubo
Assistant Referees: AJ Jacobs, Cwengile Jadezweni
TMO: Shaun Veldsman